I'm looking for a topic for a thesis paper answering a focused historical question over the early American colonial era.

The early American colonial era spanned from 1492, when Christopher Columbus and his small fleet arrived in the Caribbean, to 1763, when the end of the French and Indian Wars and the signing of the Treaty of Paris ceded total control of colonial territories east of the Mississippi River to Britain. In between those dates was the beginning of the French colonization of Canada in 1534 and France’s subsequent expansion southward into present-day America. Spanish colonization of southern latitudes also occurred during this time. The first English settlement was established at Jamestown in 1607, and the Pilgrims arrived at Massachusetts 13 years later. Developing a thesis topic that covers this 220-year span of North American history, then, allows for considerable latitude. Because this is a time in which immigration is a prominent issue, a thesis focused on the multiple examples of European immigration to North America during the early American colonial era could be contemplated. A possible thesis could center on the disparate ways each category of European immigrant interacted with native tribes and what the end result was for the tribes.
Developing a thesis statement can only really occur after some initial research or study has been completed. A thesis statement, after all, is the paper’s conclusion definitively stated in the paper’s introduction. The body is a scholarly discussion citing primary and secondary sources that aggregately supports the thesis statement. The conclusion, of course, summarizes what has been said and restates the findings. A thesis paper focused on some aspect of early American colonial history can only be divorced from the subject of relationships with indigenous peoples with great dexterity. Those relationships can provide the basis, therefore, for a thesis paper comparing the relative experiences of the Spanish, French, British, and English Pilgrims (the British Crown being a distinct category from the English settlers escaping persecution). Such a topic, however, may be unwieldy given the parameters set forth by the instructor. In this, case, comparing only two of the categories of settlers might be an option, such as contrasting attitudes toward indigenous tribes on the part of the Spanish and French, the French and British, or the British Crown and the Pilgrims.
Another possible direction for a thesis paper could focus on imperialism and the competition for new territories and resources. The Spanish, French and British were locked in an intensely competitive struggle for advantage, and a paper that examines the relationships among the three can be an option, especially if one considers the cost of overseas exploration and expansion to the empires. In other words, was it worth it? The costs of colonizing territories and fighting each other as well as the native tribes could be compared to the value of those colonial holdings.
Another possible topic for a thesis paper could focus solely on the long-term ramifications for the native tribes of European colonialization. This might require a paper that transcends the time frame specified, but a paper examining the marginalization (and worse) of Native American tribes during the period of early American colonization would certainly establish the setting and context in which the myriad social and cultural problems affecting tribes today originated.
http://www.historyplace.com/unitedstates/revolution/rev-early.htm

https://www.scholastic.com/teachers/articles/teaching-content/history-native-americans/