According to Two-Bit, what is the safest thing to be when one meets up with a group of social outcasts in an alley?

Short Answer: Another social outcast
In chapter 7, Ponyboy is doing the dishes, and Two-Bit tells him a story while he sharpens his prized switchblade. Two-Bit begins by telling Ponyboy that he was walking by himself down a back alley the other night when he ran into a group of hoods. As Two-Bit walked by them, he said "Howdy" and they just looked at each other. One of the guys then turned to Two-Bit and told him that if he didn't look exactly like them, they would have jumped him. The guy also said that the reason they decided not to jump Two-Bit was that they figured he didn't have anything worth taking. Two-Bit then poses a question to Ponyboy by asking him "What's the safest thing to be when one is met by a gang of social outcasts in an alley?" Pony responds by saying a "judo expert," and Two-Bit corrects him by saying, "No, another social outcast!"