What are the major themes of this novel?

Kevin Wilson's 2011 novel The Family Fang is concerned with the nature of art and artists and what it means when the lines between art and life are blurred and children are involved.
The parents of the family are performance artists so immersed in their work that they fail to consider the damage they do to their children by dehumanizing them and drawing no distinction between their art and their family's collective life.  The son and daughter are conditioned to become collaborators in their parents' public exploits and ultimately suffer for it, each in their own way.
The novel is, at least in part, an indictment of the egotism inherent in artists. The mother and father's self-absorption ultimately severs their family's relationships and suggests a connection between creation and destruction.